Peptide Libraray

MSSV

General Information

DRACP ID DRACP01048

Peptide Name MSSV

Sequence OLeu-V-NMeLeu-FL

Sequence Length 16

UniProt ID Not available

PubChem CID Not available

Origin Fusarium spp. isolated from Korean potato

Type Native peptide

Classification

Active ACP

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
5637	Bladder carcinoma	Carcinoma	IC50=20 μg/mL	MTT assay	24h	1
T24	Bladder carcinoma	Carcinoma	IC50=20 μg/mL	MTT assay	24h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism MSSV inhibited the proliferation of both bladder cancer 5637 and T24 cells, which was attributed to the G1-phase cell cycle arrest, apoptosis induction, and alteration of mitogen-activated protein kinases (MAPKs) and protein kinase b (AKT) signaling pathways.

Nature Anticancer; Antitumor

Structure Information

PDB ID Not available

Predicted Structure Not available

Helicity Not available

Linear/Cyclic Cyclic

Disulfide/Other Bond OLeu1<--->Leu5

N-terminal Modification None

C-terminal Modification None

Other Modification OLeu=leucic acid component; NMeLeu=N-methylleucine;

Chiral Mix

Physicochemical Information

Formula C41H50N8S

Absent amino acids ACDEGHIKPQRSTWY

Common amino acids L

Mass 95469

Pl 6.11

Basic residues 0

Acidic residues 0

Hydrophobic residues 5

Net charge 0

Boman Index 1749

Hydrophobicity 105

Aliphatic Index 91.25

Half Life
/

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 1

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 33430488

Title N-Methylsansalvamide, a cytotoxic cyclic depsipeptide from a marine fungus of the genus fusarium

Doi 10.1016/s0031-9422(00)00280-6

Year 2021

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available