This work is licensed under a Creative Commons Attribution 4.0 International License.
VS-9
General Information
DRACP ID DRACP01050
Peptide Name VS-9
Sequence VKLRSLLCS
Sequence Length 9
UniProt ID Not available
PubChem CID Not available
Origin garlic
Type Native peptide
Classification
Active ACP Cancer targeted peptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Molt-4 | Adult T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | Leukemia | IC50=0.84 mM | MTT assay | 48h | 1 |
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia | Leukemia | IC50=1.57 mM | MTT assay | 48h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity PBMC: IC50>2.0 mM
Target groove of the BH3 domain on target proteins
Affinity Not available
Mechanism VS-9 could induce apoptosis and upregulate mRNA levels of caspase 3, caspase 8, caspase 9, and Bax while downregulating Bcl-2, Bcl-xL, and Bcl-w.
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C44H83N13O12S
Absent amino acids ADEFGHIMNPQTWY
Common amino acids L
Mass 116116
Pl 9.83
Basic residues 2
Acidic residues 0
Hydrophobic residues 4
Net charge 2
Boman Index -719
Hydrophobicity 90
Aliphatic Index 162.22
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 33595876
Title A novel peptide isolated from garlic shows anticancer effect against leukemic cell lines via interaction with Bcl-2 family proteins
Year 2021
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.