Peptide Libraray

LvHemB1

General Information

DRACP ID DRACP01051

Peptide Name LvHemB1

Sequence DVNFLLHKIYGNIRY

Sequence Length 15

UniProt ID Not available

PubChem CID Not available

Origin Litopenaeus vannamei

Type Native peptide

Classification

Active ACP

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
HeLa	Human papillomavirus-related endocervical adenocarcinoma	Carcinoma	70.30% decrease=50μg/mL	MTS assay	24h	1
EC109	Esophageal cancer	Carcinoma	49.01% decrease=50μg/mL	MTS assay	24h	1
HepG2	Hepatoblastoma	Blastoma	53.26% decrease=50μg/mL	MTS assay	24h	1
EJ	Bladder carcinoma	Carcinoma	78.44% decrease=50μg/mL	MTS assay	24h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity THLE-3: 30.83% decrease=50μg/mL

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer; Antibacterial

Structure Information

PDB ID Not available

Predicted Structure DRACP01051

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C88H133N23O22

Absent amino acids ACEMPQSTW

Common amino acids ILNY

Mass 211507

Pl 9.15

Basic residues 3

Acidic residues 1

Hydrophobic residues 6

Net charge 2

Boman Index -1977

Hydrophobicity -10

Aliphatic Index 123.33

Half Life
Mammalian: 100 hour
Yeast: >20 hour
E.coli: >10 hour

Extinction Coefficient cystines 2980

Absorbance 280nm 212.86

Polar residues 5

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 33630204

Title LvHemB1, a novel cationic antimicrobial peptide derived from the hemocyanin of Litopenaeus vannamei, induces cancer cell death by targeting mitochondrial voltage-dependent anion channel 1

Doi 10.1007/s10565-021-09588-y

Year 2022

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available