This work is licensed under a Creative Commons Attribution 4.0 International License.
Dermaseptin S4-COOH
General Information
DRACP ID DRACP01054
Peptide Name Dermaseptin S4-COOH
Sequence ALWMTLLKKVLKAAAKAALNAVLVGANA
Sequence Length 28
UniProt ID P80280
PubChem CID Not available
Origin Phyllomedusa sauvagii
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| SW620 | Colon adenocarcinoma | Carcinoma | 66.5±5.32% Cytotoxicity=256 µg/ml | MTT assay | 3h | 1 |
Hemolytic Activity Human erythrocytes: 80±3.32% Hemolysis=256 µg/ml
Normal (non-cancerous) Cytotoxicity BHK-21 BSR: 12% Cytotoxicity=10 µM; Vero cells: 50% Cytotoxicity=7.50 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal; Antiviral
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C132H229N35O32S
Absent amino acids CDEFHIPQRSY
Common amino acids A
Mass 333238
Pl 11.28
Basic residues 4
Acidic residues 0
Hydrophobic residues 19
Net charge 4
Boman Index 2550
Hydrophobicity 103.21
Aliphatic Index 146.79
Half Life
Mammalian: 7.2 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 5500
Absorbance 280nm 203.7
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 33774792
Title Evaluating the effect of dermaseptin S4 and its derivatives on multidrug-resistant bacterial strains and on the colon cancer cell line SW620
Doi 10.1007/s11356-021-13683-2 Abstract
Year 2021
Literature 2
Pubmed ID 29439871
Title Dermaseptins as potential antirabies compounds
Doi 10.1016/j.vaccine.2018.01.066
Year 2019
Literature 3
Pubmed ID 23161023
Title In vitro antiviral activity of dermaseptin S(4) and derivatives from amphibian skin against herpes simplex virus type 2
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.