This work is licensed under a Creative Commons Attribution 4.0 International License.
Brevinin-2DYb
General Information
DRACP ID DRACP01057
Peptide Name Brevinin-2DYb
Sequence GLFDVVKGVLKGAGKNVAGSLLEQLKCKLSGGC
Sequence Length 33
UniProt ID Not available
PubChem CID Not available
Origin Rana dybowskii
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | IC50=24.01 µM | MTT assay | 24h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=37.84 µM | MTT assay | 24h | 1 |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=23.26 µM | MTT assay | 24h | 1 |
| LoVo | Colon adenocarcinoma | Carcinoma | IC50=35.05 µM | MTT assay | 24h | 1 |
Hemolytic Activity Sheep erythrocytes: <10% Hemolysis=256 µM
Normal (non-cancerous) Cytotoxicity HEK293T cells: IC50=50.66 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys27<--->Cys33
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C145H250N40O42S2
Absent amino acids HIMPRTWY
Common amino acids G
Mass 386094
Pl 9.55
Basic residues 5
Acidic residues 2
Hydrophobic residues 13
Net charge 3
Boman Index -84
Hydrophobicity 39.7
Aliphatic Index 112.12
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 125
Absorbance 280nm 3.91
Polar residues 12
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 34073203
Title Prediction of Anticancer Peptides with High Efficacy and Low Toxicity by Hybrid Model Based on 3D Structure of Peptides
Year 2021
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.