This work is licensed under a Creative Commons Attribution 4.0 International License.
PTN
General Information
DRACP ID DRACP01059
Peptide Name PTN
Sequence ILGTILGLLKGL
Sequence Length 12
UniProt ID Not available
PubChem CID Not available
Origin venom glands of three different wasps
Type Native peptide
Classification
Active ACP Cancer targeted peptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | CC50=15.9±1.1 µM | MTT assay | 24h | 1 |
Hemolytic Activity hRBC(human blood red cells): CC50>>500 µM
Normal (non-cancerous) Cytotoxicity MCF-10A : CC50=96.8±3.5 µM (testing time is 24 h)
Target lipids
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C58H107N13O14
Absent amino acids ACDEFHMNPQRSVWY
Common amino acids L
Mass 140698
Pl 9.7
Basic residues 1
Acidic residues 0
Hydrophobic residues 7
Net charge 1
Boman Index 2914
Hydrophobicity 185
Aliphatic Index 227.5
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 34090029
Title Protonectin peptides target lipids, act at the interface and selectively kill metastatic breast cancer cells while preserving morphological integrity
Doi 10.1016/j.jcis.2021.05.115
Year 2021
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.