This work is licensed under a Creative Commons Attribution 4.0 International License.
LK-13
General Information
DRACP ID DRACP01063
Peptide Name LK-13
Sequence CLLKKLLKKLLKK
Sequence Length 13
UniProt ID Not available
PubChem CID Not available
Origin AMP
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HCT 116 | Colon carcinoma | Carcinoma | IC50=23±2 µM | MTT assay | 72h | 1 |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=83±9 µM | MTT assay | 72h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity HDF: IC50>100 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C75H145N19O14S
Absent amino acids ADEFGHIMNPQRSTVWY
Common amino acids KL
Mass 178340
Pl 11.1
Basic residues 6
Acidic residues 0
Hydrophobic residues 6
Net charge 6
Boman Index -250
Hydrophobicity 14.62
Aliphatic Index 180
Half Life
Mammalian: 1.2 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 34509120
Title Rationally designed short cationic α-helical peptides with selective anticancer activity
Doi 10.1016/j.jcis.2021.08.200
Year 2022
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.