This work is licensed under a Creative Commons Attribution 4.0 International License.
PCC-1
General Information
DRACP ID DRACP01065
Peptide Name PCC-1
Sequence KKRKKKAFALKFVVDLI
Sequence Length 17
UniProt ID Not available
PubChem CID Not available
Origin insect-derived peptide
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| SK-MEL-28 | Cutaneous melanoma | Carcinoma | IC50=50.8 µM | MTT assay | 24, 48h | 1 |
| G-361 | Melanoma | Carcinoma | IC50=57.8 µM | MTT assay | 24, 48h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity HaCaT: not induce toxicity
Target Not available
Affinity Not available
Mechanism PCC-1 induces cell proliferation inhibition, apoptosis, and cell cycle arrest by downregulating Sp1 expression in the melanoma cell lines SK-MEL-28 and G361.
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C98H170N26O20
Absent amino acids CEGHMNPQSTWY
Common amino acids K
Mass 231817
Pl 11.46
Basic residues 7
Acidic residues 1
Hydrophobic residues 9
Net charge 6
Boman Index -2452
Hydrophobicity -10
Aliphatic Index 114.71
Half Life
Mammalian: 1.2 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 34531430
Title Hybrid Anticancer Peptides DN1 and DN4 Exert Selective Cytotoxicity Against Hepatocellular Carcinoma Cells by Inducing Both Intrinsic and Extrinsic Apoptotic Pathways
Doi 10.1007/s10989-021-10288-8
Year 2021
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.