This work is licensed under a Creative Commons Attribution 4.0 International License.
IKIR
General Information
DRACP ID DRACP01068
Peptide Name IKIR
Sequence IKIRIKIRIKIR
Sequence Length 12
UniProt ID Not available
PubChem CID Not available
Origin cationic amphiphilic peptides
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HCT 116 | Colon carcinoma | Carcinoma | IC50=20.9±2.0 µM | MTT assay | 72h | 1 |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=14.5±2.3 µM | MTT assay | 72h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity HDF: IC50=38.6±0.2 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C72H140N24O13
Absent amino acids ACDEFGHLMNPQSTVWY
Common amino acids I
Mass 174645
Pl 12.82
Basic residues 6
Acidic residues 0
Hydrophobic residues 6
Net charge 6
Boman Index -3189
Hydrophobicity 15
Aliphatic Index 195
Half Life
Mammalian: 20 hour
Yeast: 30 min
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 34715505
Title Correlation between the secondary structure and surface activity of β-sheet forming cationic amphiphilic peptides and their anticancer activity
Doi 10.1016/j.colsurfb.2021.112165
Year 2022
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.