LRLR

General Information


DRACP ID  DRACP01073

Peptide Name   LRLR

Sequence  LRLRLRLRLRLR

Sequence Length  12

UniProt ID  Not available

PubChem CID  Not available

Origin  cationic amphiphilic peptides

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
HCT 116 Colon carcinoma Carcinoma IC50=31.8±2.9 µM MTT assay 72h 1
HeLa Human papillomavirus-related endocervical adenocarcinoma Carcinoma IC50>40 µM MTT assay 72h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  HDF: IC50=22.7±2.4 µM

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  DRACP01073

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C72H140N30O13

Absent amino acids  ACDEFGHIKMNPQSTVWY

Common amino acids  LR

Mass  183048

Pl  13.2

Basic residues  6

Acidic residues  0

Hydrophobic residues  6

Net charge  6

Boman Index  -6000

Hydrophobicity  -35

Aliphatic Index  195

Half Life 
  Mammalian: 5.5 hour
  Yeast: 3 min
  E.coli: 2 min

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  0

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 34715505

Title  Correlation between the secondary structure and surface activity of β-sheet forming cationic amphiphilic peptides and their anticancer activity

Doi 10.1016/j.colsurfb.2021.112165

Year  2022

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.