This work is licensed under a Creative Commons Attribution 4.0 International License.
Shiva-1
General Information
DRACP ID DRACP01076
Peptide Name Shiva-1
Sequence MPRWRLFRRIDRVGKQIKQGILRAGPAIALVGDARAVG
Sequence Length 38
UniProt ID Not available
PubChem CID Not available
Origin Magainin
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia | Leukemia | IC50=28.7 µM | MTT assay | 96 h | 1 |
| BTS-30 | Breast Cancer | Carcinoma | IC50=56 µM | MTT assay | 96 h | 1 |
| HRT-18 | Colon adenocarcinoma | Carcinoma | IC50=49.3 µM | MTT assay | 96 h | 1 |
| DLD-1 | Colon adenocarcinoma | Carcinoma | IC50>100 µM | MTT assay | 96 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C189H322N64O45S
Absent amino acids CEHNSTY
Common amino acids R
Mass 490327
Pl 12.63
Basic residues 9
Acidic residues 2
Hydrophobic residues 17
Net charge 7
Boman Index -7609
Hydrophobicity -9.74
Aliphatic Index 107.89
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 5500
Absorbance 280nm 148.65
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 7849420
Title Preliminary experimental anticancer activity of cecropins
Doi Not available
Year 1994
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.