This work is licensed under a Creative Commons Attribution 4.0 International License.
Cecropin P1
General Information
DRACP ID DRACP01077
Peptide Name Cecropin P1
Sequence SWLSKTAKKLENSAKKRISEGIAIAIQGGPR
Sequence Length 31
UniProt ID P14661
PubChem CID Not available
Origin Small Intestine of Pig
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia | Leukemia | IC50=93 µM | MTT assay | 96 h | 1 |
| BTS-30 | Breast Cancer | Carcinoma | IC50>100 µM | MTT assay | 96 h | 1 |
| HRT-18 | Colon adenocarcinoma | Carcinoma | IC50>100 µM | MTT assay | 96 h | 1 |
| DLD-1 | Colon adenocarcinoma | Carcinoma | IC50>100 µM | MTT assay | 96 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C147H253N45O43
Absent amino acids CDFHMVY
Common amino acids K
Mass 387419
Pl 11.34
Basic residues 7
Acidic residues 2
Hydrophobic residues 11
Net charge 5
Boman Index -5765
Hydrophobicity -55.81
Aliphatic Index 88.39
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 5500
Absorbance 280nm 183.33
Polar residues 9
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 7849420
Title Preliminary experimental anticancer activity of cecropins
Doi Not available
Year 1994
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.