This work is licensed under a Creative Commons Attribution 4.0 International License.
EH-APP(1-22)-Melittin (21-26)
General Information
DRACP ID DRACP01079
Peptide Name EH-APP(1-22)-Melittin (21-26)
Sequence GEILCNLCTGLINTLENLLTTKRKRQQ
Sequence Length 27
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| U-937 | Adult acute monocytic leukemi; Acute monoblastic/monocytic leukemia | Leukemia | LC=50 µM | Trypan blue assay | 1h | 1 |
| Jurkat | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | Leukemia | LC50=8 µM | Trypan blue assay | 1h | 1 |
Hemolytic Activity Human erythrocytes: 50% Hemolysis=10 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C130H230N40O41S2
Absent amino acids ADFHMPSVWY
Common amino acids L
Mass 353758
Pl 8.82
Basic residues 4
Acidic residues 2
Hydrophobic residues 8
Net charge 2
Boman Index -5204
Hydrophobicity -30
Aliphatic Index 115.56
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 125
Absorbance 280nm 4.81
Polar residues 11
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 8146160
Title Cytolytic and antibacterial activity of synthetic peptides derived from amoebapore, the pore-forming peptide of Entamoeba histolytica
Year 1994
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.