This work is licensed under a Creative Commons Attribution 4.0 International License.
EH-APP(40-64)
General Information
DRACP ID DRACP01080
Peptide Name EH-APP(40-64)
Sequence GFIATLCTKVLDFGIDKLIQLIEDK
Sequence Length 25
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| U-937 | Adult acute monocytic leukemi; Acute monoblastic/monocytic leukemia | Leukemia | LC50=80 µM | Trypan blue assay | 1h | 1 |
| Jurkat | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | Leukemia | LC50=60 µM | Trypan blue assay | 1h | 1 |
Hemolytic Activity Human erythrocytes: 10% Hemolysis=10 µm
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C129H213N29O37S
Absent amino acids HMNPRSWY
Common amino acids IL
Mass 322265
Pl 4.5
Basic residues 3
Acidic residues 4
Hydrophobic residues 12
Net charge -1
Boman Index -597
Hydrophobicity 63.6
Aliphatic Index 140.4
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 8146160
Title Cytolytic and antibacterial activity of synthetic peptides derived from amoebapore, the pore-forming peptide of Entamoeba histolytica
Year 1994
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.