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P5
General Information
DRACP ID DRACP01090
Peptide Name P5
Sequence KWKLFKKIGIGAFLHLAKKF
Sequence Length 20
UniProt ID Not available
PubChem CID Not available
Origin Ceropin A-Magainin 2
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| NCI-H128 | Lung small cell carcinoma; Small cell lung cancer | Carcinoma | IC50=2.9 µM | MTT assay | 72 h | 1 |
| NCI-H146 | Lung small cell carcinoma; Small cell lung cancer | Carcinoma | IC50=3.2 µM | MTT assay | 72 h | 1 |
| NCI-H69 | Lung small cell carcinoma; Small cell lung cancer | Carcinoma | IC50=2.9 µM | MTT assay | 72 h | 1 |
Hemolytic Activity Human red blood cells: hemolysis 1.5%(50 μg/mL); hemolysis 8%(100 μg/mL)
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C120H189N29O21
Absent amino acids CDEMNPQRSTVY
Common amino acids K
Mass 271310
Pl 11.5
Basic residues 7
Acidic residues 0
Hydrophobic residues 11
Net charge 7
Boman Index 341
Hydrophobicity 20.5
Aliphatic Index 107.5
Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 5500
Absorbance 280nm 289.47
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 9352466
Title Structure-antitumor and hemolytic activity relationships of synthetic peptides derived from cecropin A-magainin 18 and cecropin A-melittin hybrid peptides
Doi 10.1111/j.1399-3011.1997.tb01469.x
Year 1997
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.