Peptide Libraray

General Information

DRACP ID DRACP01093

Peptide Name P8

Sequence KWKKFLKIGIGKFLHLAKKF

Sequence Length 20

UniProt ID Not available

PubChem CID Not available

Origin Ceropin A-Magainin 2

Type Synthetic peptide

Classification

Active ACP

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
NCI-H128	Lung small cell carcinoma; Small cell lung cancer	Carcinoma	IC50=2.3 µM	MTT assay	72 h	1
NCI-H146	Lung small cell carcinoma; Small cell lung cancer	Carcinoma	IC50=1.8 µM	MTT assay	72 h	1
NCI-H69	Lung small cell carcinoma; Small cell lung cancer	Carcinoma	IC50=2.6 µM	MTT assay	72 h	1

Hemolytic Activity Human red blood cells: hemolysis 2.4%(50 μg/mL); hemolysis 13.7%(100 μg/mL)

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer; Antibacterial

Structure Information

PDB ID Not available

Predicted Structure DRACP01093

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C123H196N30O21

Absent amino acids CDEMNPQRSTVY

Common amino acids K

Mass 277019

Pl 11.58

Basic residues 8

Acidic residues 0

Hydrophobic residues 10

Net charge 8

Boman Index -395

Hydrophobicity -8

Aliphatic Index 102.5

Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min

Extinction Coefficient cystines 5500

Absorbance 280nm 289.47

Polar residues 2

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 9352466

Title Structure-antitumor and hemolytic activity relationships of synthetic peptides derived from cecropin A-magainin 21 and cecropin A-melittin hybrid peptides

Doi 10.1111/j.1399-3011.1997.tb01469.x

Year 1997

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available