This work is licensed under a Creative Commons Attribution 4.0 International License.
DRS B4
General Information
DRACP ID DRACP01094
Peptide Name DRS B4
Sequence ALWKDILKNVGKAAGKAVLNTVTDMVNQ
Sequence Length 28
PubChem CID Not available
Origin Dermaseptins B
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | Cytotoxicity=15 µM | Thymidine Incorporation assay | 6 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C133H225N37O39S
Absent amino acids CEFHPRSY
Common amino acids AKV
Mass 348035
Pl 10.33
Basic residues 4
Acidic residues 2
Hydrophobic residues 13
Net charge 2
Boman Index -2060
Hydrophobicity 7.5
Aliphatic Index 111.43
Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 5500
Absorbance 280nm 203.7
Polar residues 7
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 9614066
Title Structure, synthesis, and molecular cloning of dermaseptins B, a family of skin peptide antibiotics
Year 1998
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.