This work is licensed under a Creative Commons Attribution 4.0 International License.
DRS B3
General Information
DRACP ID DRACP01095
Peptide Name DRS B3
Sequence ALWKNMLKGIGKLAGQAALGAVKTLVGA
Sequence Length 28
UniProt ID P81485 P83641 C0HLD2
PubChem CID Not available
Origin Dermaseptins B
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | Cytotoxicity=12 µM | Thymidine Incorporation assay | 6 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C127H219N35O32S
Absent amino acids CDEFHPRSY
Common amino acids A
Mass 326224
Pl 11.28
Basic residues 4
Acidic residues 0
Hydrophobic residues 15
Net charge 4
Boman Index 2089
Hydrophobicity 65.71
Aliphatic Index 125.71
Half Life
Mammalian: 4.4 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 5500
Absorbance 280nm 203.7
Polar residues 7
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 9614066
Title Structure, synthesis, and molecular cloning of dermaseptins B, a family of skin peptide antibiotics
Year 1998
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.