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DRS S1
General Information
DRACP ID DRACP01096
Peptide Name DRS S1
Sequence ALWKTMLKKLGTMALHAGKAALGAAADTISQGTQ
Sequence Length 34
UniProt ID P24302
PubChem CID Not available
Origin Dermaseptins B
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | Not available | Thymidine Incorporation assay | 6 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C152H257N43O44S2
Absent amino acids CEFNPRVY
Common amino acids A
Mass 404395
Pl 10.8
Basic residues 5
Acidic residues 1
Hydrophobic residues 15
Net charge 4
Boman Index -555
Hydrophobicity 18.53
Aliphatic Index 92.35
Half Life
Mammalian: 4.4 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 5500
Absorbance 280nm 166.67
Polar residues 9
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 9614066
Title Structure, synthesis, and molecular cloning of dermaseptins B, a family of skin peptide antibiotics
Year 1998
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.