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Temporin-ALa
General Information
DRACP ID DRACP01097
Peptide Name Temporin-ALa
Sequence FLPIVGKLLSGLSGLL
Sequence Length 16
UniProt ID Not available
PubChem CID Not available
Origin Amolops loloensis; Amolops jingdongensis; Amolops mantzorum
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| SW620 | Colon adenocarcinoma | Carcinoma | IC50>61.46 µM | MTT assay | Not available | 1 |
| HSC-4 | Tongue squamous cell carcinoma; Squamous cell carcinoma of the oral tongue | Carcinoma | IC50>61.46 µM | MTT assay | Not available | 1 |
Hemolytic Activity Human erythrocytes: 25% Hemolysis=61.46 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C79H135N17O19
Absent amino acids ACDEHMNQRTWY
Common amino acids L
Mass 189479
Pl 9.7
Basic residues 1
Acidic residues 0
Hydrophobic residues 9
Net charge 1
Boman Index 3193
Hydrophobicity 162.5
Aliphatic Index 188.75
Half Life
Mammalian: 4.4 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Anticancer Activities of Antimicrobial BmKn2 Peptides Against Oral and Colon Cancer Cells
Year 2014
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.