This work is licensed under a Creative Commons Attribution 4.0 International License.
CPe-III(CPe-III-S)
General Information
DRACP ID DRACP01098
Peptide Name CPe-III(CPe-III-S)
Sequence RQSHFANAQP
Sequence Length 10
UniProt ID Not available
PubChem CID Not available
Origin Chickpea (Cicer arietinum L.)
Type Native peptide
Classification
Active ACP Cancer targeted peptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | EC50=2.38 μmol/mL | MTT assay | 72h | 1 |
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | EC50=1.50 μmol/mL | MTT assay | 72h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target p53 protein
Affinity Not available
Mechanism the bioactive peptide combined the DNA binding domain of p53 protein by hydrogen bonds, induced the expression of p53 protein and facilitated its stability so that it inhibited the cell proliferation.
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C49H74N18O15
Absent amino acids CDEGIKLMTVWY
Common amino acids AQ
Mass 131595
Pl 10.55
Basic residues 2
Acidic residues 0
Hydrophobic residues 3
Net charge 2
Boman Index -3410
Hydrophobicity -142
Aliphatic Index 20
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Antioxidant activity and anti-proliferative effect of a bioactive peptide from chickpea (Cicer arietinum L.)
Doi 10.1016/j.foodres.2015.09.027
Year 2015
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.