This work is licensed under a Creative Commons Attribution 4.0 International License.
INKKI peptide
General Information
DRACP ID DRACP01103
Peptide Name INKKI peptide
Sequence INKKI
Sequence Length 5
UniProt ID Not available
PubChem CID Not available
Origin β-Casein
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=3.78 µg/mL | MTT assay | 24h | 1 |
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | IC50=3.53 μg/mL | MTT assay | 24h | 1 |
| T-47D | Invasive breast carcinoma of no special type | Carcinoma | IC50=3.26 μg/mL | MTT assay | 24h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=3.07 μg/mL | MTT assay | 24h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Fibroblast FN-1 (human): no effect (testing time is 24 h); Endothelial CRL 1730 (human) : no effect (testing time is 24 h)
Target Not available
Affinity Not available
Mechanism By apoptosis via mitochondrial pathway in a caspase-independent manner
Nature Anticancer; Antitumor
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C28H54N8O7
Absent amino acids ACDEFGHLMPQRSTVWY
Common amino acids IK
Mass 68632
Pl 10.81
Basic residues 2
Acidic residues 0
Hydrophobic residues 2
Net charge 2
Boman Index -790
Hydrophobicity -46
Aliphatic Index 156
Half Life
Mammalian:
Yeast:
E.coli:
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Evaluation of the antitumor and antiproliferative effects of the INKKI peptide on MCF-7 breast adenocarcinoma cells
Doi Not available
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.