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Hepcidin TH1-5
General Information
DRACP ID DRACP01104
Peptide Name Hepcidin TH1-5
Sequence GIKCRFCCGCCTPGICGVCCRF
Sequence Length 22
UniProt ID Not available
PubChem CID Not available
Origin Skin Secretion of the African Frog, Kassina senegalensis
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=20 μg/mL | MTT assay | 72h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C94H153N29O24S8
Absent amino acids ADEHLMNQSWY
Common amino acids C
Mass 270469
Pl 8.21
Basic residues 3
Acidic residues 0
Hydrophobic residues 5
Net charge 3
Boman Index -412
Hydrophobicity 100
Aliphatic Index 48.64
Half Life
Mammalian: 20 hour
Yeast: 30 min
E.coli: >10 hour
Extinction Coefficient cystines 500
Absorbance 280nm 23.81
Polar residues 13
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Hepcidin TH1-5 Induces Apoptosis and Activate Caspase-9 in MCF-7 Cells
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.