This work is licensed under a Creative Commons Attribution 4.0 International License.
ND5
General Information
DRACP ID DRACP01110
Peptide Name ND5
Sequence GLFDRVKKRKSLF
Sequence Length 13
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Hep-G2 | Hepatoblastoma; Hepatoblastoma | Blastoma | IC50>256 µg/mL | MTT assay | 24h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Vero: IC50>256 µg/mL; THLE-3: IC50>256 µg/mL
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C74H124N22O17
Absent amino acids ACEHIMNPQTWY
Common amino acids K
Mass 180815
Pl 11.75
Basic residues 5
Acidic residues 1
Hydrophobic residues 5
Net charge 4
Boman Index -3783
Hydrophobicity -61.54
Aliphatic Index 82.31
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Hybrid Anticancer Peptides DN1 and DN4 Exert Selective Cytotoxicity Against Hepatocellular Carcinoma Cells by Inducing Both Intrinsic and Extrinsic Apoptotic Pathways
Doi 10.1007/s10989-021-10288-8
Year 2021
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.