This work is licensed under a Creative Commons Attribution 4.0 International License.
DN1
General Information
DRACP ID DRACP01111
Peptide Name DN1
Sequence ILGKIVKKLVSDF
Sequence Length 13
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Hep-G2 | Hepatoblastoma; Hepatoblastoma | Blastoma | IC50=152.17±7.73 µg/mL | MTT assay | 24h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Vero: IC50>256 µg/mL; THLE-3: IC50>256 µg/mL
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C70H122N16O17
Absent amino acids ACEHMNPQRTWY
Common amino acids K
Mass 167407
Pl 10.51
Basic residues 3
Acidic residues 1
Hydrophobic residues 7
Net charge 2
Boman Index 291
Hydrophobicity 87.69
Aliphatic Index 164.62
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Hybrid Anticancer Peptides DN1 and DN4 Exert Selective Cytotoxicity Against Hepatocellular Carcinoma Cells by Inducing Both Intrinsic and Extrinsic Apoptotic Pathways
Doi 10.1007/s10989-021-10288-8
Year 2021
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.