DN2

General Information


DRACP ID  DRACP01115

Peptide Name   DN2

Sequence  ILGKIWKKLVSDF

Sequence Length  13

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
Hep-G2 Hepatoblastoma; Hepatoblastoma Blastoma IC50>256 µg/mL MTT assay 24h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Vero: IC50=156.33±4.33 µg/mL; THLE-3: IC50=105.33±4.42 µg/mL

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  DRACP01115

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C76H123N17O17

Absent amino acids  ACEHMNPQRTY

Common amino acids  K

Mass  176115

Pl  10.51

Basic residues  3

Acidic residues  1

Hydrophobic residues  7

Net charge  2

Boman Index  120

Hydrophobicity  48.46

Aliphatic Index  142.31

Half Life 
  Mammalian: 20 hour
  Yeast: 30 min
  E.coli: >10 hour

Extinction Coefficient cystines  5500

Absorbance 280nm  458.33

Polar residues  2

Amino acid distribution



Literature Information


Literature 1

Pubmed ID Not available

Title  Hybrid Anticancer Peptides DN1 and DN4 Exert Selective Cytotoxicity Against Hepatocellular Carcinoma Cells by Inducing Both Intrinsic and Extrinsic Apoptotic Pathways

Doi 10.1007/s10989-021-10288-8

Year  2021

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.