This work is licensed under a Creative Commons Attribution 4.0 International License.
Lycosin-II
General Information
DRACP ID DRACP01121
Peptide Name Lycosin-II
Sequence VWLSALKFIGKHLAKHQLSKL
Sequence Length 21
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HCT 116 | Colon carcinoma | Carcinoma | IC50=70.79 µg/mL | MTT assay | 24h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity IC50 on PBMCs was = 92.0 ± 39.6 μM
Target Not available
Affinity Not available
Mechanism Lycosin-II Suppresses the Growth of Tumor Cells and Kills them Through Membrane Disruption and Apoptosis Induction
Nature Anticancer; Antitumor
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C116H189N31O25
Absent amino acids CDEMNPRTY
Common amino acids L
Mass 277491
Pl 11.28
Basic residues 6
Acidic residues 0
Hydrophobic residues 11
Net charge 6
Boman Index -43
Hydrophobicity 27.14
Aliphatic Index 134.76
Half Life
Mammalian: 2.8 hour
Yeast: 10 min
E.coli: 2 min
Extinction Coefficient cystines 5500
Absorbance 280nm 275
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Lycosin-II Suppresses the Growth of Tumor Cells and Kills them Through Membrane Disruption and Apoptosis Induction
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.