VKVR

General Information


DRACP ID  DRACP01123

Peptide Name   VKVR

Sequence  VKDGYIVDDKNCAYFCGRNAYCDDECEKNGAESGYCQWAGVYGNACWCYKLPDKVPIRVPGRCNG

Sequence Length  65

UniProt ID  G4V3T9 

PubChem CID  Not available

Origin  Scorpion

Type  Native peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
Mouse S180 sarcoma Mouse S180 sarcoma Sarcoma At a dose of 4.4 mg/kg body weight, the tumor weight inhibition rate was 46% Antitumor in vivo 7 days Patent

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antitumor



Structure Information


PDB ID  Not available

Predicted Structure  DRACP01123

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C313H463N87O97S8

Absent amino acids  HMT

Common amino acids  CG

Mass  839491

Pl  4.9

Basic residues  8

Acidic residues  9

Hydrophobic residues  16

Net charge  -1

Boman Index  -11883

Hydrophobicity  -58.92

Aliphatic Index  48

Half Life 
  Mammalian: 4.4 hour
  Yeast: >20 hour
  E.coli: >10 hour

Extinction Coefficient cystines  20440

Absorbance 280nm  319.38

Polar residues  28

Amino acid distribution



Literature Information


Literature 1

Pubmed ID Not available

Title  Not available

Doi Not available

Year  Not available

Patent

Patent ID CN102690342B

Patent Title  Anti-cancer analgesic peptide VKVR, its preparation method and application  

Other Iinformation  Granted Patent; Family: 2s/2ex; Family Jurisdictions: CN; Legal Status: Active; Application No: 201110069002; Filed: Mar 22, 2011; Published: Oct 29, 2014; Earliest Priority: Mar 22, 2011; Granted: Oct 29, 2014

Other Published ID  CN102690342B 




DRACP is developed by Dr.Zheng's team.