This work is licensed under a Creative Commons Attribution 4.0 International License.
OPB
General Information
DRACP ID DRACP01125
Peptide Name OPB
Sequence GNKKWEQKQVQIKTLEGEFSVTMWSS
Sequence Length 26
PubChem CID Not available
Origin YY1 protein
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | As shown in figure 3 | WST-1 assay | 5~6 days | Patent |
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | As shown in figure 4 | WST-1 assay | 5~6 days | Patent |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Is nontoxic to normal breast cell
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C137H214N36O42S
Absent amino acids ACDHPRY
Common amino acids K
Mass 351557
Pl 9.37
Basic residues 4
Acidic residues 3
Hydrophobic residues 7
Net charge 1
Boman Index -5144
Hydrophobicity -96.54
Aliphatic Index 52.31
Half Life
Mammalian: 2.8 hour
Yeast: 10 min
E.coli: 2 min
Extinction Coefficient cystines 11000
Absorbance 280nm 440
Polar residues 8
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID CN105601724B
Patent Title Anticancer active OPB (oligopeptidase B) oligopeptide and expression vector and application thereof
Other Iinformation Granted Patent; Family: 2s / 2ex; Family Jurisdictions: CN; Legal Status: Active; Application No: 201610018929 Filed: Jan 12, 2016 Published: Jun 7, 2019 Earliest Priority: Jan 12, 2016; Granted: Jun 7, 2019
Other Published ID CN105601724B
This work is licensed under a Creative Commons Attribution 4.0 International License.