This work is licensed under a Creative Commons Attribution 4.0 International License.
CMAP-L-24
General Information
DRACP ID DRACP01129
Peptide Name CMAP-L-24
Sequence KKFFKKMKKLVKKFF
Sequence Length 15
UniProt ID Not available
PubChem CID Not available
Origin Not available
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | At a concentration of 100μM, the 24 h cell viability is approximately 35%(Duncan-test,P<0.01) | MTT assay | 24 h | Patent |
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | At a concentration of 100μM, the 24 h cell viability is approximately 66%(Duncan-test,P<0.01) | MTT assay | 24 h | Patent |
| BT-474 | Invasive breast carcinoma of no special type | Carcinoma | At a concentration of 100μM, the 24 h cell viability is approximately 50%(Duncan-test,P<0.01) | MTT assay | 24 h | Patent |
| ZR-75-1 | Invasive breast carcinoma of no special type | Carcinoma | At a concentration of 100μM, the 24 h cell viability is approximately 41%(Duncan-test,P<0.01) | MTT assay | 24 h | Patent |
Hemolytic Activity Human red blood cells: no hemolytic activity at 12.5 μM, 25 μM, 50 μM, 100 μM
Normal (non-cancerous) Cytotoxicity Less toxic than CDDP on human normal MCF10A and 293FT
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C100H163N23O16S
Absent amino acids ACDEGHINPQRSTWY
Common amino acids K
Mass 222548
Pl 11.65
Basic residues 8
Acidic residues 0
Hydrophobic residues 6
Net charge 8
Boman Index -2117
Hydrophobicity -67.33
Aliphatic Index 45.33
Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID CN106831946A
Patent Title Anticancer peptide as well as preparation method and application thereof
Other Iinformation Granted Patent; Family: 2s / 2ex; Family Jurisdictions: CN; Legal Status: Active; Application No: 201611198223; Filed: Dec 22, 2016; Published: Nov 10, 2020; Earliest Priority: Dec 22, 2016; Granted: Nov 10, 2020
Other Published ID CN106831946B
This work is licensed under a Creative Commons Attribution 4.0 International License.