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v6Pep-2
General Information
DRACP ID DRACP01168
Peptide Name v6Pep-2
Sequence CNEWQLKSC
Sequence Length 9
UniProt ID Not available
PubChem CID Not available
Origin Screen of phage display peptide library
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | Kd=17.69 | CD44v6 specifically binds to assay | Not available | Patent |
| 4T1 | Malignant neoplasms of the mouse mammary gland | Carcinoma | Kd=29.12 | CD44v6 specifically binds to assay | Not available | Patent |
| PANC-1 | Pancreatic ductal adenocarcinoma | Carcinoma | Kd=6.655 | CD44v6 specifically binds to assay | Not available | Patent |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C46H71N13O15S2
Absent amino acids ADFGHIMPRTVY
Common amino acids C
Mass 125315
Pl 6.14
Basic residues 1
Acidic residues 1
Hydrophobic residues 2
Net charge 0
Boman Index -1813
Hydrophobicity -81.11
Aliphatic Index 43.33
Half Life
Mammalian: 1.2 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 5625
Absorbance 280nm 703.13
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID EP3733685A1
Patent Title Peptides Binding to Cd44v6 and Use Thereof
Other Iinformation Patent Application; Family: 6s / 7ex; Family Jurisdictions: EP, KR, US; Legal Status: Pending; Application No: 18889460; Filed: Dec 17, 2018; Published: Nov 4, 2020; Earliest Priority: Dec 15, 2017
Other Published ID EP3733685A4 KR102194025B1 KR20190072467A US2021163535A1
This work is licensed under a Creative Commons Attribution 4.0 International License.