This work is licensed under a Creative Commons Attribution 4.0 International License.
HDH-LGBP-A2
General Information
DRACP ID DRACP01170
Peptide Name HDH-LGBP-A2
Sequence WLWKAIWKLLK
Sequence Length 11
UniProt ID Not available
PubChem CID Not available
Origin Not available
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | The non- survival rate in the HeLa cell it exposed to the HDH-LGBP-A2 peptide of the concentration of 10 μg/ml, 25 μg/ml, 50 μg/ml are 16%, 99%, 98% | MTS assay | 24 h | Patent |
| A549 | Lung adenocarcinoma | Carcinoma | The non- survival rate in the HeLa cell it exposed to the HDH-LGBP-A2 peptide of the concentration of 10 μg/ml, 25 μg/ml, 50 μg/ml are 13%, 99%, 99% | MTS assay | 24 h | Patent |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity In the concentration of 50 μg/ml, the normal cell (HUVEC) the viability was 47.9%
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C78H117N17O12
Absent amino acids CDEFGHMNPQRSTVY
Common amino acids KLW
Mass 166346
Pl 11.1
Basic residues 3
Acidic residues 0
Hydrophobic residues 8
Net charge 3
Boman Index 1183
Hydrophobicity 30
Aliphatic Index 150.91
Half Life
Mammalian: 1.2 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 16500
Absorbance 280nm 1650
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID KR101749548B1
Patent Title Antimicrobial Peptide Derived From Abalone Lipopolysaccharide and Beta-Glucan Binding Protein Nucleic Acid Encoding the Peptide and Uses Thereof
Other Iinformation Granted Patent; Family: 4s / 4ex; Family Jurisdictions: KR, JP; Legal Status: Active; Application No: 20150145265; Filed: Oct 19, 2015; Published: Jun 21, 2017; Earliest Priority: Oct 19, 2015; Granted: Jun 21, 2017
Other Published ID JP2017077236A JP6045678B1 KR101749548B1
This work is licensed under a Creative Commons Attribution 4.0 International License.