p53 TAD(50-54) Ala-substituted peptide

General Information


DRACP ID  DRACP01174

Peptide Name   p53 TAD(50-54) Ala-substituted peptide

Sequence  AEQAA

Sequence Length  5

UniProt ID  Not available

PubChem CID  Not available

Origin  p57 protein

Type  Native peptide

Classification

  

Active ACP Cancer targeted peptides



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
MCF-7 Invasive breast carcinoma of no special type Carcinoma When the peptide concentrations were 1 μM, 10 μM, 100 μM, 300μM, the Cell viability(%) was 90%, 95%, 81%, 79% MTT assay 24 h Patent
HCT 116 Colon carcinoma Carcinoma When the peptide concentrations were 1 μM, 10 μM, 100 μM, 300μM, the Cell viability(%) was 95%, 89%, 82%, 70% MTT assay 24 h Patent
A549 Lung adenocarcinoma Carcinoma When the peptide concentrations were 1 μM, 10 μM, 100 μM, 300μM, the Cell viability(%) was 100%, 100%, 90%, 82% MTT assay 24 h Patent
SNU-719 Gastric tubular adenocarcinoma Carcinoma When the peptide concentrations were 1 μM, 10 μM, 100 μM, 300μM, the Cell viability(%) was 92%, 90%, 82%, 80% MTT assay 24 h Patent

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  mdm2 (mouse double minute 2)

Affinity  Not available

Mechanism  Not available

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  DRACP01174

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C19H32N6O9

Absent amino acids  CDFGHIKLMNPRSTVWY

Common amino acids  A

Mass  56004

Pl  3.85

Basic residues  0

Acidic residues  1

Hydrophobic residues  3

Net charge  -1

Boman Index  -692

Hydrophobicity  -32

Aliphatic Index  60

Half Life 
  Mammalian: 30 hour
  Yeast: >20 hour
  E.coli: >10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  0

Amino acid distribution



Literature Information


Literature 1

Pubmed ID Not available

Title  Not available

Doi Not available

Year  Not available

Patent

Patent ID KR20050098766A

Patent Title  Peptides for Inhibiting Mdm2 Function

Other Iinformation  Patent Application; Family: 5s / 5ex; Family Jurisdictions: KR, US, WO; Legal Status: Inactive; Application No: 20050000931; Filed: Jan 5, 2005; Published: Oct 12, 2005; Earliest Priority: Apr 6, 2004; Granted: Dec 27, 2007

Other Published ID  KR100788928B1  US2009030181A1  US8598127B2  WO2005097820A1 




DRACP is developed by Dr.Zheng's team.