This work is licensed under a Creative Commons Attribution 4.0 International License.
p53 TAD(50-54) Trp-substituted peptide
General Information
DRACP ID DRACP01176
Peptide Name p53 TAD(50-54) Trp-substituted peptide
Sequence WEQWW
Sequence Length 5
UniProt ID Not available
PubChem CID Not available
Origin p61 protein
Type Native peptide
Classification
Active ACP Cancer targeted peptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | When the peptide concentrations were 1 μM, 10 μM, 100 μM, 300μM, the Cell viability(%) was 100%, 90%, 32%, 8% | MTT assay | 24 h | Patent |
| HCT 116 | Colon carcinoma | Carcinoma | When the peptide concentrations were 1 μM, 10 μM, 100 μM, 300μM, the Cell viability(%) was 97%, 89%, 45%, 8% | MTT assay | 24 h | Patent |
| A549 | Lung adenocarcinoma | Carcinoma | When the peptide concentrations were 1 μM, 10 μM, 100 μM, 300μM, the Cell viability(%) was 90%, 81%, 10%, 2% | MTT assay | 24 h | Patent |
| SNU-719 | Gastric tubular adenocarcinoma | Carcinoma | When the peptide concentrations were 1 μM, 10 μM, 100 μM, 300μM, the Cell viability(%) was 95%, 87%, 43%, 2% | MTT assay | 24 h | Patent |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target mdm2 (mouse double minute 2)
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C43H47N9O9
Absent amino acids ACDFGHIKLMNPRSTVY
Common amino acids W
Mass 90543
Pl 3.85
Basic residues 0
Acidic residues 1
Hydrophobic residues 3
Net charge -1
Boman Index -536
Hydrophobicity -194
Aliphatic Index 0
Half Life
Mammalian: 20 hour
Yeast: 30 min
E.coli: >10 hour
Extinction Coefficient cystines 16500
Absorbance 280nm 4125
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID KR20050098766A
Patent Title Peptides for Inhibiting Mdm2 Function
Other Iinformation Patent Application; Family: 5s / 5ex; Family Jurisdictions: KR, US, WO; Legal Status: Inactive; Application No: 20050000931; Filed: Jan 5, 2005; Published: Oct 12, 2005; Earliest Priority: Apr 6, 2004; Granted: Dec 27, 2007
Other Published ID KR100788928B1 US2009030181A1 US8598127B2 WO2005097820A1
This work is licensed under a Creative Commons Attribution 4.0 International License.