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B9
General Information
DRACP ID DRACP01185
Peptide Name B9
Sequence GNPCGESCVYLPCITTVVGCSCQNSVCYHN
Sequence Length 30
UniProt ID Not available
PubChem CID Not available
Origin Hedyotis biflora
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| BxPC-3 | Pancreatic ductal adenocarcinoma | Carcinoma | IC50=1.54 μM | MTT assay | 72h | Patent |
| Capan-2 | Pancreatic ductal adenocarcinoma | Carcinoma | IC50=1.32 μM | MTT assay | 72h | Patent |
| MOH-1 | Pancreatic adenocarcinoma | Carcinoma | IC50=1.14 μM | MTT assay | 72h | Patent |
| PANC-1 | Pancreatic ductal adenocarcinoma | Carcinoma | IC50=2.01 μM | MTT assay | 72h | Patent |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C129H200N36O44S6
Absent amino acids ADFKMRW
Common amino acids C
Mass 366904
Pl 5.35
Basic residues 1
Acidic residues 1
Hydrophobic residues 6
Net charge 0
Boman Index -1605
Hydrophobicity 28.67
Aliphatic Index 64.67
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 3355
Absorbance 280nm 115.69
Polar residues 19
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Novel cyclotides from Hedyotis biflora inhibit proliferation and migration of pancreatic cancer cell in vitro and in vivo
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.