HYL-17

General Information


DRACP ID  DRACP01191

Peptide Name   HYL-17

Sequence  GIMSⓍLMKⓍLAAHIAK

Sequence Length  16

UniProt ID  Not available

PubChem CID  Not available

Origin  AMP

Type  Synthetic peptide

Classification

  

Active ACP Stapled Peptides



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
A549 Lung adenocarcinoma Carcinoma IC50=5.56±0.41 µmol/L MTT assay 72h Patent
Hep-G2 Hepatoblastoma; Hepatoblastoma Blastoma IC50=9.70±0.50 µmol/L MTT assay 72h Patent
HCT 116 Colon carcinoma Carcinoma IC50=1.54±0.32 µmol/L MTT assay 72h Patent

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Human Splenic Fibroblasts (HSF): IC50=12.78±0.33 µg/mL; Endometrial epithelial cells(HEEC): IC50=2.66±0.34 µg/mL; HPDE6c7 Human Pancreatic Duct Epithelial Cell: IC50=3.45±0.20 µg/mL; Normal Human Hepatic Cell (Lo-2): IC50=2.91±0.07 µg/mL; NCM460: IC50=3.04±0.10 µg/mL; CCD-19Lu: IC50=4.76±0.03 µg/mL

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antitumor; Antimicrobial



Structure Information


PDB ID  Not available

Predicted Structure  Not available

Helicity  Not available

Linear/Cyclic  Cyclic (Stapled)

Disulfide/Other Bond  Stapled: Ⓧ(5) and Ⓧ (9) are cross-linked by hydrocarbon stapling

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  Ⓧ=S5=(S)-N-Fmoc-2-(4-pentenyl)alanine

Chiral  L



Physicochemical Information


Formula  C66H114N18O14S2

Absent amino acids  CDEFNPQRTVWY

Common amino acids  A

Mass  193562

Pl  10.81

Basic residues  3

Acidic residues  0

Hydrophobic residues  7

Net charge  3

Boman Index  1159

Hydrophobicity  85

Aliphatic Index  116.25

Half Life 
  /

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  2

Amino acid distribution



Literature Information


Literature 1

Pubmed ID Not available

Title  Structural modification and antitumor activity of antimicrobial peptide HYL

Doi 10.1016/j.cclet.2019.10.013

Year  2020

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.