This work is licensed under a Creative Commons Attribution 4.0 International License.
GW-A5
General Information
DRACP ID DRACP01207
Peptide Name GW-A5
Sequence GATYAKKIIKTITKIATTAW
Sequence Length 20
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| J5 [Human hepatocellular carcinoma] | Hepatocellular carcinoma | Carcinoma | IC50=28.9 μM | MTT assay | 24 h | Patent |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity NIH 3T3: As show in fig.3
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C102H171N25O27
Absent amino acids CDEFHLMNPQRSV
Common amino acids T
Mass 251873
Pl 10.87
Basic residues 4
Acidic residues 0
Hydrophobic residues 9
Net charge 4
Boman Index -500
Hydrophobicity 17.5
Aliphatic Index 98
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 6990
Absorbance 280nm 367.89
Polar residues 7
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID TWI448297B
Patent Title A method of using novel synthetic peptides for the preparation of drugs with anti-liver cancer activity
Other Iinformation Granted Patent; Family: 2s / 2ex; Family Jurisdictions: TW; Legal Status: Active; Application No: 99121957; Filed: Jul 5, 2010; Published: Aug 11, 2014; Earliest Priority: Jul 5, 2010; Granted: Aug 11, 2014
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.