Peptide Libraray

General Information

DRACP ID DRACP01208

Peptide Name M2

Sequence GIGKFLHSAKKWGKAFVGEIMNS

Sequence Length 23

UniProt ID Not available

PubChem CID Not available

Origin Xenopus laevis

Type Native peptide

Classification

Active ACP

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
J5 [Human hepatocellular carcinoma]	Hepatocellular carcinoma	Carcinoma	IC50=128.9 μM	MTT assay	24 h	Patent
Huh-7	Adult hepatocellular carcinoma; Adult hepatocellular carcinoma	Carcinoma	IC50=145.2 μM	MTT assay	24 h	Patent

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity NIH 3T3: As show in fig.3

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer

Structure Information

PDB ID Not available

Predicted Structure DRACP01208

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C116H181N31O29S

Absent amino acids CDPQRTY

Common amino acids GK

Mass 289856

Pl 10.8

Basic residues 5

Acidic residues 1

Hydrophobic residues 9

Net charge 4

Boman Index -1029

Hydrophobicity -7.83

Aliphatic Index 72.17

Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour

Extinction Coefficient cystines 5500

Absorbance 280nm 250

Polar residues 7

Amino acid distribution

Literature Information

Literature 1

Pubmed ID Not available

Title Not available

Doi Not available

Year Not available

Patent

Patent ID TWI448297B

Patent Title A method of using novel synthetic peptides for the preparation of drugs with anti-liver cancer activity

Other Iinformation Granted Patent; Family: 2s / 2ex; Family Jurisdictions: TW; Legal Status: Active; Application No: 99121957; Filed: Jul 5, 2010; Published: Aug 11, 2014; Earliest Priority: Jul 5, 2010; Granted: Aug 11, 2014

Other Published ID Not available