M2a

General Information


DRACP ID  DRACP01209

Peptide Name   M2a

Sequence  GIGKFLHSAKKWGKAFVGEIMNS

Sequence Length  23

UniProt ID  Not available

PubChem CID  Not available

Origin  Xenopus laevis

Type  Native peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
J5 [Human hepatocellular carcinoma] Hepatocellular carcinoma Carcinoma IC50=96.0 μM MTT assay 24 h Patent

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  NIH 3T3: As show in fig.3

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  DRACP01209

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C116H181N31O29S

Absent amino acids  CDPQRTY

Common amino acids  GK

Mass  289856

Pl  10.8

Basic residues  5

Acidic residues  1

Hydrophobic residues  9

Net charge  4

Boman Index  -1029

Hydrophobicity  -7.83

Aliphatic Index  72.17

Half Life 
  Mammalian: 30 hour
  Yeast: >20 hour
  E.coli: >10 hour

Extinction Coefficient cystines  5500

Absorbance 280nm  250

Polar residues  7

Amino acid distribution



Literature Information


Literature 1

Pubmed ID Not available

Title  Not available

Doi Not available

Year  Not available

Patent

Patent ID TWI448297B

Patent Title  A method of using novel synthetic peptides for the preparation of drugs with anti-liver cancer activity

Other Iinformation  Granted Patent; Family: 2s / 2ex; Family Jurisdictions: TW; Legal Status: Active; Application No: 99121957; Filed: Jul 5, 2010; Published: Aug 11, 2014; Earliest Priority: Jul 5, 2010; Granted: Aug 11, 2014

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.