This work is licensed under a Creative Commons Attribution 4.0 International License.
M2a
General Information
DRACP ID DRACP01209
Peptide Name M2a
Sequence GIGKFLHSAKKWGKAFVGEIMNS
Sequence Length 23
UniProt ID Not available
PubChem CID Not available
Origin Xenopus laevis
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| J5 [Human hepatocellular carcinoma] | Hepatocellular carcinoma | Carcinoma | IC50=96.0 μM | MTT assay | 24 h | Patent |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity NIH 3T3: As show in fig.3
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C116H181N31O29S
Absent amino acids CDPQRTY
Common amino acids GK
Mass 289856
Pl 10.8
Basic residues 5
Acidic residues 1
Hydrophobic residues 9
Net charge 4
Boman Index -1029
Hydrophobicity -7.83
Aliphatic Index 72.17
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 5500
Absorbance 280nm 250
Polar residues 7
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID TWI448297B
Patent Title A method of using novel synthetic peptides for the preparation of drugs with anti-liver cancer activity
Other Iinformation Granted Patent; Family: 2s / 2ex; Family Jurisdictions: TW; Legal Status: Active; Application No: 99121957; Filed: Jul 5, 2010; Published: Aug 11, 2014; Earliest Priority: Jul 5, 2010; Granted: Aug 11, 2014
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.