GW-Q6

General Information


DRACP ID  DRACP01210

Peptide Name   GW-Q6

Sequence  GIKIAKKAITIAKKIAKIYW

Sequence Length  20

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
J5 [Human hepatocellular carcinoma] Hepatocellular carcinoma Carcinoma IC50=24.3 μM MTT assay 24 h Patent
Huh-7 Adult hepatocellular carcinoma; Adult hepatocellular carcinoma Carcinoma IC50=107.4 μM MTT assay 24 h Patent

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  NIH 3T3: As show in fig.3

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  DRACP01210

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C110H189N27O23

Absent amino acids  CDEFHLMNPQRSV

Common amino acids  IK

Mass  259699

Pl  11.13

Basic residues  6

Acidic residues  0

Hydrophobic residues  11

Net charge  6

Boman Index  402

Hydrophobicity  37.5

Aliphatic Index  137

Half Life 
  Mammalian: 30 hour
  Yeast: >20 hour
  E.coli: >10 hour

Extinction Coefficient cystines  6990

Absorbance 280nm  367.89

Polar residues  3

Amino acid distribution



Literature Information


Literature 1

Pubmed ID Not available

Title  Not available

Doi Not available

Year  Not available

Patent

Patent ID TWI448297B

Patent Title  A method of using novel synthetic peptides for the preparation of drugs with anti-liver cancer activity

Other Iinformation  Granted Patent; Family: 2s / 2ex; Family Jurisdictions: TW; Legal Status: Active; Application No: 99121957; Filed: Jul 5, 2010; Published: Aug 11, 2014; Earliest Priority: Jul 5, 2010; Granted: Aug 11, 2014

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.