This work is licensed under a Creative Commons Attribution 4.0 International License.
Ple
General Information
DRACP ID DRACP01211
Peptide Name Ple
Sequence GWGSFFKKAAHVGKHVGKAALTHYL
Sequence Length 25
PubChem CID Not available
Origin winter flounder
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| J5 [Human hepatocellular carcinoma] | Hepatocellular carcinoma | Carcinoma | IC50=54.9 μM | MTT assay | 24 h | Patent |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity NIH 3T3: As show in fig.3
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C129H192N36O29
Absent amino acids CDEIMNPQR
Common amino acids AGK
Mass 313945
Pl 10.87
Basic residues 7
Acidic residues 0
Hydrophobic residues 11
Net charge 7
Boman Index -508
Hydrophobicity -6.8
Aliphatic Index 70.4
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 6990
Absorbance 280nm 291.25
Polar residues 7
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID TWI448297B
Patent Title A method of using novel synthetic peptides for the preparation of drugs with anti-liver cancer activity
Other Iinformation Granted Patent; Family: 2s / 2ex; Family Jurisdictions: TW; Legal Status: Active; Application No: 99121957; Filed: Jul 5, 2010; Published: Aug 11, 2014; Earliest Priority: Jul 5, 2010; Granted: Aug 11, 2014
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.