Peptide Libraray

Ple-a

General Information

DRACP ID DRACP01212

Peptide Name Ple-a

Sequence GWGSFFKKAAHVGKHVGKAALTHYL

Sequence Length 25

UniProt ID P81941 Q90ZY0

PubChem CID Not available

Origin winter flounder

Type Native peptide

Classification

Active ACP

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
J5 [Human hepatocellular carcinoma]	Hepatocellular carcinoma	Carcinoma	IC50=11.0 μM	MTT assay	24 h	Patent
Huh-7	Adult hepatocellular carcinoma; Adult hepatocellular carcinoma	Carcinoma	IC50=60.0 μM	MTT assay	24 h	Patent

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity NIH 3T3: As show in fig.3

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer

Structure Information

PDB ID Not available

Predicted Structure DRACP01212

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C129H192N36O29

Absent amino acids CDEIMNPQR

Common amino acids AGK

Mass 313945

Pl 10.87

Basic residues 7

Acidic residues 0

Hydrophobic residues 11

Net charge 7

Boman Index -508

Hydrophobicity -6.8

Aliphatic Index 70.4

Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour

Extinction Coefficient cystines 6990

Absorbance 280nm 291.25

Polar residues 7

Amino acid distribution

Literature Information

Literature 1

Pubmed ID Not available

Title Not available

Doi Not available

Year Not available

Patent

Patent ID TWI448297B

Patent Title A method of using novel synthetic peptides for the preparation of drugs with anti-liver cancer activity

Other Iinformation Granted Patent; Family: 2s / 2ex; Family Jurisdictions: TW; Legal Status: Active; Application No: 99121957; Filed: Jul 5, 2010; Published: Aug 11, 2014; Earliest Priority: Jul 5, 2010; Granted: Aug 11, 2014

Other Published ID Not available