This work is licensed under a Creative Commons Attribution 4.0 International License.
Penetratin, Antp, Sequence 3 from Patent US 20030077289
General Information
DRACP ID DRACP01237
Peptide Name Penetratin, Antp, Sequence 3 from Patent US 20030077289
Sequence RQIKIWFQNRRMKWKK
Sequence Length 16
UniProt ID P31256 Q28599 P31262 Q28600 P15860 P09636 P18865 P09637 P07548 P09077 P81192 Q24645 P02833 Q1KKX9 O13074 Q9PWD3 Q1KKX0 P09013 Q9IA23 P09014 Q1KL14 Q1KKY0 A2D5Y4 P20719 A2D5K9
PubChem CID 25242319
Origin Antennapedia homeodomain
Type Native peptide
Classification
Cell-penetrating peptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa WT | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | 50% Cytotoxicity=281 ± 56.5 μM | MTS/PMS assay | 1 h | 1 |
Hemolytic Activity Human erythrocytes: HD50>128 μM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C104H168N34O20S
Absent amino acids ACDEGHLPSTVY
Common amino acids K
Mass 251448
Pl 12.83
Basic residues 7
Acidic residues 0
Hydrophobic residues 5
Net charge 7
Boman Index -6485
Hydrophobicity -173.13
Aliphatic Index 48.75
Half Life
Mammalian: >20 hour
Yeast: >20 hour
E.coli: ?
Extinction Coefficient cystines 11000
Absorbance 280nm 733.33
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23085001
Title Antimicrobial and cell-penetrating properties of penetratin analogs: effect of sequence and secondary structure
Doi 10.1016/j.bbamem.2012.10.010
Year 2013
Patent
Patent ID US 2003/0077289 A1
Patent Title Use of cell-penetrating peptides to generate antitumor immunity.
Other Iinformation Granted Patent Family: 6s / 6ex; Family Jurisdictions: CN, WO, AU, US; Legal Status: Discontinued; Application No: 7755502; Filed:Feb 15, 2002; Published: Apr 24, 2003; Earliest Priority: Feb 15, 2001
Other Published ID CN1309417C CN1503628A WO2002064057A2 WO2002064057A3
External Code
DBAASP ID DBAASPS_6203
This work is licensed under a Creative Commons Attribution 4.0 International License.