Sequence 1 from Patent US 20100279918

General Information


DRACP ID  DRACP01307

Peptide Name   Sequence 1 from Patent US 20100279918

Sequence  CREKA

Sequence Length  5

UniProt ID  A2AAJ9  P97607  Q2U3V3  P0C584  Q8INB9  Q46802  Q8IYB5  A8ZWA3  Q91VZ6  A7NSB7  A5URC6  Q9SN11  Q7NI14  A2ASS6  Q8WZ42  Q9BXT5  Q558U1  Q550L8  B1I493  P04323 

PubChem CID  Not available

Origin  Synthetic construct

Type  Synthetic peptide

Classification

  

Tumor-homing peptides



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
MCF-7 Invasive breast carcinoma of no special type Carcinoma IC50>200 µM MTT assay 48 h 1
CAPAN-1 Pancreatic ductal adenocarcinoma Carcinoma IC50>200 µM MTT assay 48 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  NIH 3T3: IC50>200 µM

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  DRACP01307

Helicity  Not available

Linear/Cyclic  Not available

Disulfide/Other Bond  Not available

N-terminal Modification  Not available

C-terminal Modification  Not available

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C23H43N9O8S

Absent amino acids  DFGHILMNPQSTVWY

Common amino acids  ACEKR

Mass  67724

Pl  8.55

Basic residues  2

Acidic residues  1

Hydrophobic residues  1

Net charge  1

Boman Index  -2419

Hydrophobicity  -152

Aliphatic Index  20

Half Life 
  Mammalian: 1.2 hour
  Yeast: >20 hour
  E.coli: >10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  1

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 24480922

Title  Identification of BP16 as a non-toxic cell-penetrating peptide with highly efficient drug delivery properties

Doi 10.1039/c3ob42422g

Year  2014

Patent

Patent ID US 2010/0279918 A1

Patent Title  Chimeric Constructs Between Cancer-Homing Peptides and Cell-Penetrating Peptides Coupled to Anticancer Drugs and/or Diagnostic Agent/Agents.

Other Iinformation  Granted Patent Family: 7s / 7ex; Family Jurisdictions: DE, EP, WO, AT, US; Legal Status: Discontinued; Application No: 22536707; Filed:Mar 20, 2007; Published: Nov 4, 2010; Earliest Priority: Mar 20, 2006;

Other Published ID  DE602007011901D1  EP1991586A1  EP1991586B1  WO2007108749A1  WO2007108749A8 




DRACP is developed by Dr.Zheng's team.