This work is licensed under a Creative Commons Attribution 4.0 International License.
Sequence 1 from Patent US 20100279918
General Information
DRACP ID DRACP01307
Peptide Name Sequence 1 from Patent US 20100279918
Sequence CREKA
Sequence Length 5
UniProt ID A2AAJ9 P97607 Q2U3V3 P0C584 Q8INB9 Q46802 Q8IYB5 A8ZWA3 Q91VZ6 A7NSB7 A5URC6 Q9SN11 Q7NI14 A2ASS6 Q8WZ42 Q9BXT5 Q558U1 Q550L8 B1I493 P04323
PubChem CID Not available
Origin Synthetic construct
Type Synthetic peptide
Classification
Tumor-homing peptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50>200 µM | MTT assay | 48 h | 1 |
| CAPAN-1 | Pancreatic ductal adenocarcinoma | Carcinoma | IC50>200 µM | MTT assay | 48 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity NIH 3T3: IC50>200 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Not available
Disulfide/Other Bond Not available
N-terminal Modification Not available
C-terminal Modification Not available
Other Modification None
Chiral L
Physicochemical Information
Formula C23H43N9O8S
Absent amino acids DFGHILMNPQSTVWY
Common amino acids ACEKR
Mass 67724
Pl 8.55
Basic residues 2
Acidic residues 1
Hydrophobic residues 1
Net charge 1
Boman Index -2419
Hydrophobicity -152
Aliphatic Index 20
Half Life
Mammalian: 1.2 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 24480922
Title Identification of BP16 as a non-toxic cell-penetrating peptide with highly efficient drug delivery properties
Year 2014
Patent
Patent ID US 2010/0279918 A1
Patent Title Chimeric Constructs Between Cancer-Homing Peptides and Cell-Penetrating Peptides Coupled to Anticancer Drugs and/or Diagnostic Agent/Agents.
Other Iinformation Granted Patent Family: 7s / 7ex; Family Jurisdictions: DE, EP, WO, AT, US; Legal Status: Discontinued; Application No: 22536707; Filed:Mar 20, 2007; Published: Nov 4, 2010; Earliest Priority: Mar 20, 2006;
Other Published ID DE602007011901D1 EP1991586A1 EP1991586B1 WO2007108749A1 WO2007108749A8
This work is licensed under a Creative Commons Attribution 4.0 International License.