This work is licensed under a Creative Commons Attribution 4.0 International License.
Sequence 10 from Patent US 20100279918
General Information
DRACP ID DRACP01315
Peptide Name Sequence 10 from Patent US 20100279918
Sequence MANLGYWLLALFVTMWTDVGLCKKRPKP
Sequence Length 28
UniProt ID P04925
PubChem CID Not available
Origin Mus sp.
Type Native peptide
Classification
Active ACP
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Not available
Disulfide/Other Bond Not available
N-terminal Modification Not available
C-terminal Modification Not available
Other Modification None
Chiral L
Physicochemical Information
Formula C153H239N37O35S3
Absent amino acids EHIQS
Common amino acids L
Mass 373478
Pl 10.13
Basic residues 4
Acidic residues 1
Hydrophobic residues 12
Net charge 3
Boman Index -41
Hydrophobicity 30
Aliphatic Index 97.5
Half Life
Mammalian: 5.5 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 12490
Absorbance 280nm 462.59
Polar residues 7
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID US 2010/0279918 A1
Patent Title Chimeric Constructs Between Cancer-Homing Peptides and Cell-Penetrating Peptides Coupled to Anticancer Drugs and/or Diagnostic Agent/Agents.
Other Iinformation Granted Patent Family: 7s / 7ex; Family Jurisdictions: DE, EP, WO, AT, US; Legal Status: Discontinued; Application No: 22536707; Filed:Mar 20, 2007; Published: Nov 4, 2010; Earliest Priority: Mar 20, 2006;
Other Published ID DE602007011901D1 EP1991586A1 EP1991586B1 WO2007108749A1 WO2007108749A8
This work is licensed under a Creative Commons Attribution 4.0 International License.