This work is licensed under a Creative Commons Attribution 4.0 International License.
Sema3A(aa371-377) -nLytic
General Information
DRACP ID DRACP01366
Peptide Name Sema3A(aa371-377) -nLytic
Sequence GRVPYPRGGLLkLLKklLKKLlKL
Sequence Length 24
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Cancer targeted peptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| BXPC-3 | Pancreatic ductal adenocarcinoma | Carcinoma | IC50=14.7μM | WST-8 assay | 48h | Patent |
| CFPAC-1 | Cystic fibrosis; Pancreatic ductal adenocarcinoma; Cystic fibrosis | Carcinoma | IC50=9.2μM | WST-8 assay | 48h | Patent |
| PANC-1 | Pancreatic ductal adenocarcinoma | Carcinoma | IC50=14.1μM | WST-8 assay | 48h | Patent |
| SU.86.86 | Pancreatic adenocarcinoma | Carcinoma | IC50=8.0μM | WST-8 assay | 48h | Patent |
| BT-20 | Invasive breast carcinoma of no special type | Carcinoma | IC50=11.4μM | WST-8 assay | 48h | Patent |
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | IC50=8.1μM | WST-8 assay | 48h | Patent |
| SKBR-3 | Breast adenocarcinoma | Carcinoma | IC50=14.5μM | WST-8 assay | 48h | Patent |
| T-47D | Invasive breast carcinoma of no special type | Carcinoma | IC50=3.7μM | WST-8 assay | 48h | Patent |
| HuCC-T1 | Intrahepatic cholangiocarcinoma; Cholangiocarcinoma | Carcinoma | IC50=7.9μM | WST-8 assay | 48h | Patent |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Pancreatic epithelium: IC50>50μM; HEK293T: IC50>20μM
Target Epidermal growth factor receptor (EGFR)
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification l=D-Leucine; k=D-Lysine
Chiral Mix
Physicochemical Information
Formula C108H184N30O18
Absent amino acids ACDEFHIMNQSTW
Common amino acids L
Mass 260127
Pl 11.84
Basic residues 6
Acidic residues 0
Hydrophobic residues 8
Net charge 6
Boman Index -1088
Hydrophobicity 2.08
Aliphatic Index 125.83
Half Life
/
Extinction Coefficient cystines 1490
Absorbance 280nm 64.78
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID US 2011/0319336 A1
Patent Title Selective anticancer chimeric peptide.
Other Iinformation Granted Patent Family: 19s / 19ex; Family Jurisdictions: US, JP, EP, WO, CN; Legal Status: Active; Application No: 200913132580; Filed: Dec 3, 2009; Published: Dec 29, 2011; Earliest Priority: Dec 3, 2008; Granted: May 7, 2013
Other Published ID CN102238965A EP2370107A2 WO2010064207A2 WO2010064207A3
This work is licensed under a Creative Commons Attribution 4.0 International License.