This work is licensed under a Creative Commons Attribution 4.0 International License.
Sequence 59 from Patent US 20110319336
General Information
DRACP ID DRACP01367
Peptide Name Sequence 59 from Patent US 20110319336
Sequence KAYARIGNSYFK
Sequence Length 12
UniProt ID Q60864 P31948 Q3ZBZ8 O35814 Q7ZWU1 O54981 Q4R8N7
PubChem CID Not available
Origin Synthetic construct
Type Synthetic peptide
Classification
Active ACP
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Not available
Disulfide/Other Bond Not available
N-terminal Modification Not available
C-terminal Modification Not available
Other Modification None
Chiral L
Physicochemical Information
Formula C66H100N18O17
Absent amino acids CDEHLMPQTVW
Common amino acids AKY
Mass 161401
Pl 10.45
Basic residues 3
Acidic residues 0
Hydrophobic residues 4
Net charge 3
Boman Index -2388
Hydrophobicity -72.5
Aliphatic Index 49.17
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 2980
Absorbance 280nm 270.91
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID US 2011/0319336 A1
Patent Title Selective anticancer chimeric peptide.
Other Iinformation Granted Patent Family: 19s / 19ex; Family Jurisdictions: US, JP, EP, WO, CN; Legal Status: Active; Application No: 200913132580; Filed: Dec 3, 2009; Published: Dec 29, 2011; Earliest Priority: Dec 3, 2008; Granted: May 7, 2013
Other Published ID CN102238965A EP2370107A2 WO2010064207A2 WO2010064207A3
This work is licensed under a Creative Commons Attribution 4.0 International License.