This work is licensed under a Creative Commons Attribution 4.0 International License.
lytic
General Information
DRACP ID DRACP01372
Peptide Name lytic
Sequence KLlLKlLkkLLKlLKKK
Sequence Length 17
UniProt ID Native peptide
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Cancer targeted peptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| H322 | Minimally invasive lung adenocarcinoma | Carcinoma | IC50=21±3.2μM | WST-8 assay | 72h | Patent |
| BT-20 | Invasive breast carcinoma of no special type | Carcinoma | IC50=20±2.9μM | WST-8 assay | 72h | Patent |
| U251 | Astrocytoma | Carcinoma | IC50=20±2.5μM | WST-8 assay | 72h | Patent |
| H460 | Lung large cell carcinoma | Carcinoma | IC50=20±1.6μM | WST-8 assay | 72h | Patent |
| BXPC-3 | Pancreatic ductal adenocarcinoma | Carcinoma | IC50=32±1.6μM | WST-8 assay | 72h | Patent |
| SU.86.86 | Pancreatic adenocarcinoma | Carcinoma | IC50=28±0.5μM | WST-8 assay | 72h | Patent |
| LNCaP | Prostate carcinoma | Carcinoma | IC50=16±2.5μM | WST-8 assay | 72h | Patent |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity WI-38: IC50=100±3.1μM; MRC-5: 110±8.1μM; HEK293: IC50=58±0.3μM
Target Epidermal growth factor receptor (EGFR)
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification l=D-Leucine; k=D-Lysine
Chiral Mix
Physicochemical Information
Formula C72H130N18O8
Absent amino acids ACDEFGHIMNPQRSTVWY
Common amino acids KL
Mass 166152
Pl 11.5
Basic residues 6
Acidic residues 0
Hydrophobic residues 6
Net charge 6
Boman Index -378
Hydrophobicity -3.53
Aliphatic Index 137.65
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID US 2011/0319336 A1
Patent Title Selective anticancer chimeric peptide.
Other Iinformation Granted Patent Family: 19s / 19ex; Family Jurisdictions: US, JP, EP, WO, CN; Legal Status: Active; Application No: 200913132580; Filed: Dec 3, 2009; Published: Dec 29, 2011; Earliest Priority: Dec 3, 2008; Granted: May 7, 2013
Other Published ID CN102238965A EP2370107A2 WO2010064207A2 WO2010064207A3
This work is licensed under a Creative Commons Attribution 4.0 International License.