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IL4-lytic(D, L)
General Information
DRACP ID DRACP01376
Peptide Name IL4-lytic(D, L)
Sequence KQLIRFLKRLDRNGGGKLlLKlLkkLLKlLKKK
Sequence Length 33
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Cancer targeted peptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| BXPC-3 | Pancreatic ductal adenocarcinoma | Carcinoma | IC50=6.8±0.3μM | WST-8 assay | 72h | Patent |
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | IC50=5.7±0.4μM | WST-8 assay | 72h | Patent |
| A172 | Glioblastoma | Blastoma | IC50=6.8±0.4μM | WST-8 assay | 72h | Patent |
| KCCT873 | Not available | Not available | IC50=5.9±0.6μM | WST-8 assay | 72h | Patent |
| U251 | Astrocytoma | Carcinoma | IC50=6.6±0.4μM | WST-8 assay | 72h | Patent |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity PE: IC50>20μM; HEK293T: IC50=14.2±1.3μM; WI-38: IC50=16.1±0.5μM
Target Interleukin-4 (IL4) Receptor
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification l=D-Leucine; k=D-Lysine
Chiral Mix
Physicochemical Information
Formula C154H271N47O28
Absent amino acids ACEHMPSTVWY
Common amino acids L
Mass 380012
Pl 12.34
Basic residues 11
Acidic residues 1
Hydrophobic residues 11
Net charge 10
Boman Index -5506
Hydrophobicity -45.15
Aliphatic Index 118.18
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID US 2011/0319336 A1
Patent Title Selective anticancer chimeric peptide.
Other Iinformation Granted Patent Family: 19s / 19ex; Family Jurisdictions: US, JP, EP, WO, CN; Legal Status: Active; Application No: 200913132580; Filed: Dec 3, 2009; Published: Dec 29, 2011; Earliest Priority: Dec 3, 2008; Granted: May 7, 2013
Other Published ID CN102238965A EP2370107A2 WO2010064207A2 WO2010064207A3
This work is licensed under a Creative Commons Attribution 4.0 International License.