This work is licensed under a Creative Commons Attribution 4.0 International License.
nLytic
General Information
DRACP ID DRACP01379
Peptide Name nLytic
Sequence LLkLLKklLKKLlKL
Sequence Length 15
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Cancer targeted peptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| BXPC-3 | Pancreatic ductal adenocarcinoma | Carcinoma | IC50=38.5μM | WST-8 assay | 48h | Patent |
| CFPAC-1 | Cystic fibrosis; Pancreatic ductal adenocarcinoma; Cystic fibrosis | Carcinoma | IC50=22.6μM | WST-8 assay | 48h | Patent |
| PANC-1 | Pancreatic ductal adenocarcinoma | Carcinoma | IC50=28.2μM | WST-8 assay | 48h | Patent |
| SU.86.86 | Pancreatic adenocarcinoma | Carcinoma | IC50=19.5μM | WST-8 assay | 48h | Patent |
| BT-20 | Invasive breast carcinoma of no special type | Carcinoma | IC50=38.0μM | WST-8 assay | 48h | Patent |
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | IC50=29.6μM | WST-8 assay | 48h | Patent |
| T-47D | Invasive breast carcinoma of no special type | Carcinoma | IC50=12.5μM | WST-8 assay | 48h | Patent |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Pancreatic epithelium: IC50>50μM
Target Epidermal growth factor receptor (EGFR)
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification l=D-Leucine; k=D-Lysine
Chiral Mix
Physicochemical Information
Formula C66H119N15O8
Absent amino acids ACDEFGHIMNPQRSTVWY
Common amino acids L
Mass 150068
Pl 11.28
Basic residues 4
Acidic residues 0
Hydrophobic residues 7
Net charge 4
Boman Index 1224
Hydrophobicity 73.33
Aliphatic Index 182
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID US 2011/0319336 A1
Patent Title Selective anticancer chimeric peptide.
Other Iinformation Granted Patent Family: 19s / 19ex; Family Jurisdictions: US, JP, EP, WO, CN; Legal Status: Active; Application No: 200913132580; Filed: Dec 3, 2009; Published: Dec 29, 2011; Earliest Priority: Dec 3, 2008; Granted: May 7, 2013
Other Published ID CN102238965A EP2370107A2 WO2010064207A2 WO2010064207A3
This work is licensed under a Creative Commons Attribution 4.0 International License.